产品名称
MARH8 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase MARCH8 (EC 6.3.2.-) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q5T0T0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5T0T0/entry
Mouse Swissprot No.
Q9DBD2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DBD2
免疫原
Synthesized peptide derived from part region of human protein
特异性
MARH8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010],
组织表达
Broadly expressed. Present in immature dendritic cells (at protein level).
细胞定位
Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein .
功能
domain:The RING-CH-type zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase that may regulate immune responses by promoting ubiquitination of MHC-II and CD86, which leads to their subsequent endocytosis and lysosomal degradation. May also promote ubiquitination and endocytosis of TFRC and FAS. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-CH-type zinc finger.,subunit:Interacts with CD86.,tissue specificity:Broadly expressed. Present in immature dendritic cells (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
