产品名称
CACNG3 Rabbit Polyclonal Antibody
别名
Voltage-dependent calcium channel gamma-3 subunit; Neuronal voltage-gated calcium channel gamma-3 subunit; Transmembrane AMPAR regulatory protein gamma-3; TARP gamma-3
蛋白名称
Voltage-dependent calcium channel gamma-3 subunit
存储缓冲液
PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10368
Human Swissprot No.
O60359
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60359/entry
Mouse Swissprot No.
Q9JJV5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JJV5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8VHX0
免疫原
Synthetic Peptide of CACNG3 AA range: 84-134
特异性
The antibody detects endogenous CACNG3 protein.
稀释度
WB 1:1000-2000 IHC 1:200-500. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
calcium voltage-gated channel auxiliary subunit gamma 3(CACNG3) Homo sapiens The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010],
组织表达
Brain,Brain cortex,Cerebellum,
细胞定位
Membrane ; Multi-pass membrane protein . Displays a somatodendritic localization and is excluded from axons in neurons. .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能
disease:Candidate gene for a familial infantile convulsive disorder with paroxysomal choreoathetosis.,function:Thought to stabilize the calcium channel in an inactivated (closed) state.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
