产品名称
BEST2 Rabbit Polyclonal Antibody
别名
Bestrophin-2; Vitelliform macular dystrophy 2-like protein 1
存储缓冲液
PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54831
Human Swissprot No.
Q8NFU1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NFU1/entry
Mouse Swissprot No.
Q8BGM5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BGM5
免疫原
Synthetic Peptide of BEST2
特异性
The antibody detects endogenous BEST2 protein.
稀释度
WB 1:500-1000 IHC 1:200-500. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008],
组织表达
Mainly confined to the retinal pigment epithelium and colon.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
function:Forms calcium-sensitive chloride channels. May conduct other physiologically significant anions such as bicarbonate.,similarity:Belongs to the bestrophin family.,tissue specificity:Mainly confined to the retinal pigment epithelium and colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
