BD-PN5680

AMPKα2 Rabbit Polyclonal Antibody

PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase

常规抗体

PRKAA2

5'-AMP-activated protein kinase catalytic subunit alpha-2

WB

Human,Mouse,Rat

PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.

5563

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5563

P54646

http://www.uniprot.org/uniprotkb/P54646/entry

Q8BRK8

http://www.uniprot.org/uniprot/Q8BRK8

Q09137

http://www.uniprot.org/uniprot/O54941Q09137

Recombinant Protein of AMPKα2

The antibody detects endogenous AMPKα2 protein.

WB 1:1000-2000

62kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],

Heart,Skeletal muscle,

Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .

Regulation of autophagy;mTOR;Insulin_Receptor;Adipocytokine;Hypertrophic cardiomyopathy (HCM);

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-172 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio.,function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterotrimer of a catalytic subunit, a beta and a gamma non-catalytic subunits.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.