产品名称
LRSM1 Rabbit Polyclonal Antibody
基因名称
LRSAM1 TAL UNQ6496/PRO21356
蛋白名称
E3 ubiquitin-protein ligase LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6UWE0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6UWE0/entry
Mouse Swissprot No.
Q80ZI6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80ZI6
免疫原
Synthesized peptide derived from part region of human protein
特异性
LRSM1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012],
组织表达
Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
细胞定位
Cytoplasm . Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (PubMed:23245322). .
功能
domain:The coiled coil domains interact with the SB domain of TSG101.,domain:The PTAP motifs mediate the binding to UEV domains.,function:E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 5 LRR (leucine-rich) repeats.,subcellular location:Displays a punctuate distribution and localizes to a submembranal ring.,subunit:Interacts with TSG101.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
