产品名称
Aurora A Rabbit Polyclonal Antibody
别名
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
基因名称
AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.20% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6790
Human Swissprot No.
O14965
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14965/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20878
Mouse Swissprot No.
P97477
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97477
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P59241
免疫原
Synthesized peptide derived from human Aurora A AA range: 65-115
特异性
This antibody detects endogenous levels of Aurora A at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Aurora A(AURKA) Homo sapiens The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.
组织表达
Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, neuron projection . Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
