产品名称
HECW1 Rabbit Polyclonal Antibody
基因名称
HECW1 KIAA0322 NEDL1
蛋白名称
E3 ubiquitin-protein ligase HECW1 (EC 6.3.2.-) (HECT, C2 and WW domain-containing protein 1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q76N89
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q76N89/entry
Mouse Swissprot No.
Q8K4P8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K4P8
免疫原
Synthesized peptide derived from part region of human protein. AA range: 1-67
特异性
HECW1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.,tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.,
组织表达
Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
功能
function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.,tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
