产品名称
TRAF7 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6Q0C0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6Q0C0/entry
Mouse Swissprot No.
Q922B6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q922B6
免疫原
Synthesized peptide derived from part region of human protein
特异性
TRAF7 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
TNF receptor associated factor 7(TRAF7) Homo sapiens Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004],
组织表达
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
细胞定位
Cytoplasmic vesicle . Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
功能
function:E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated by MAP3K3.,PTM:Ubiquitinates itself upon phosphorylation.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 TRAF-type zinc finger.,similarity:Contains 7 WD repeats.,subcellular location:Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.,subunit:Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.,tissue specificity:Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
