产品名称
ATG13 Rabbit Polyclonal Antibody
别名
Autophagy-related protein 13
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.19% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9776
Human Swissprot No.
O75143
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75143/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/51897
Mouse Swissprot No.
Q91YI1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91YI1
免疫原
Synthesized peptide derived from human ATG13 AA range: 182-232
特异性
This antibody detects endogenous levels of ATG13 at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions.
细胞定位
Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
