产品名称
HACE1 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IYU2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IYU2/entry
Mouse Swissprot No.
Q3U0D9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3U0D9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941D3ZBM7
免疫原
Synthesized peptide derived from part region of human protein
特异性
HACE1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016],
组织表达
Expressed in multiple tissues including heart, brain and kidney.
细胞定位
Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
功能
developmental stage:Expressed in fetal and pediatric kidney cells.,function:E3 ubiquitin-protein ligase that may function in cellular proteins degradation.,induction:Down-regulated in sporadic Wilms tumor.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 6 ANK repeats.,subcellular location:A significant portion localizes to the endoplasmic reticulum.,subunit:Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.,tissue specificity:Expressed in multiple tissues including heart, brain and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
