产品名称
RNF5 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase RNF5 (EC 6.3.2.-) (Protein G16) (RING finger protein 5) (Ram1 homolog) (HsRma1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q99942
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99942/entry
Mouse Swissprot No.
O35445
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35445
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5M807
免疫原
Synthesized peptide derived from part region of human protein
特异性
RNF5 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles. .
功能
function:Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.,subunit:Interacts with PXN. Interacts with Salmonella typhimurium sopA. Interacts with JAMP.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
