产品名称
RN167 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase RNF167 (EC 6.3.2.-) (RING finger protein 167) (RING105)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H6Y7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H6Y7/entry
Mouse Swissprot No.
Q91XF4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91XF4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5XIL0
免疫原
Synthesized peptide derived from part region of human protein
特异性
RN167 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
ring finger protein 167(RNF167) Homo sapiens RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008],
组织表达
Strongly expressed in the kidney and liver (at protein level).
细胞定位
Endomembrane system ; Single-pass membrane protein . Targeted to cytoplasmic membranes.
功能
function:May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.,similarity:Contains 1 PA (protease associated) domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Targeted to cytoplasmic membranes.,subunit:Interacts with SLC22A18.,tissue specificity:Strongly expressed in the kidney and liver (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
