产品名称
RN123 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase RNF123 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q5XPI4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XPI4/entry
Mouse Swissprot No.
Q5XPI3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q5XPI3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941D3ZXK7
免疫原
Synthesized peptide derived from part region of human protein
特异性
RN123 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
ring finger protein 123(RNF123) Homo sapiens The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
组织表达
Brain,Eye,Lung,Testis,Uterus,
功能
function:Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,subunit:Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with UBAC1 and CDKN1B via its N-terminal domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
