产品名称
DYLT1 Rabbit Polyclonal Antibody
基因名称
DYNLT1 TCTEL1 TCTEX-1 TCTEX1
蛋白名称
Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P63172
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P63172/entry
Mouse Swissprot No.
P51807
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51807
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9Z336
免疫原
Synthesized peptide derived from part region of human protein AA range: 1-50
特异性
DYLT1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
dynein light chain Tctex-type 1(DYNLT1) Homo sapiens This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014],
组织表达
Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).
细胞定位
Golgi apparatus . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Localizes to mitotic spindles. .
功能
similarity:Belongs to the dynein light chain Tctex-type family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains. Found in a complex with SCN10A. Interacts with DOC2A, DOC2B and SCN10A (By similarity). Interacts with PVR.,tissue specificity:Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
