产品名称
RICTR Rabbit Polyclonal Antibody
别名
Rapamycin-insensitive companion of mTOR (AVO3 homolog;hAVO3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/253260
Human Swissprot No.
Q6R327
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6R327/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/78757
Mouse Swissprot No.
Q6QI06
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6QI06
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/
免疫原
Synthesized peptide derived from human RICTR
特异性
This antibody detects endogenous levels of Human,Mouse,Monkey RICTR
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008],
功能
function:Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the pianissimo family.,subunit:Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
