产品名称
LC3A Rabbit Polyclonal Antibody
别名
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A;Autophagy-related ubiquitin-like modifier LC3 A;MAP1 light chain 3-like protein 1;MAP1A/MAP1B light chain 3 A;MAP1A/MAP1B LC3 A;Microtubule-associated protein 1 light chain 3 alpha)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84557
Human Swissprot No.
Q9H492
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H492/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66734
Mouse Swissprot No.
Q91VR7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91VR7
Rat Gene Link
https://www.uniprot.org/uniprot/362245
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6XVN8
免疫原
Synthesized peptide derived from human LC3A
特异性
This antibody detects endogenous levels of Human LC3A
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Probably involved in formation of autophagosomal vacuoles (autophagosomes).,PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.,similarity:Belongs to the MAP1 LC3 family.,subcellular location:LC3-II binds to the autophagic membranes.,subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.,tissue specificity:Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.,
组织表达
Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
细胞定位
Cytoplasmic vesicle, autophagosome membrane ; Lipid-anchor . Endomembrane system ; Lipid-anchor . Cytoplasm, cytoskeleton . LC3-II binds to the autophagic membranes. .
功能
autophagic vacuole formation,?proteolysis,?autophagy,?vacuole organization,?macromolecule catabolic process,?cellular response to starvation,?response to extracellular stimulus,?macroautophagy,?modification-dependent protein catabolic process,?protein catabolic process,?response to nutrient levels,?cellular response to extracellular stimulus,?cellular response to nutrient levels,?cellular response to stress,?response to starvation,?modification-dependent macromolecule catabolic process,?cellular protein catabolic process,?cellular macromolecule catabolic process,proteolysis involved in cellular protein catabolic process,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
