产品名称
DLRB1 Rabbit Polyclonal Antibody
基因名称
DYNLRB1 BITH DNCL2A DNLC2A ROBLD1 HSPC162
蛋白名称
Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NP97
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NP97/entry
Mouse Swissprot No.
P62627
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P62627
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P62628
免疫原
Synthesized peptide derived from part region of human protein AA range: 1-50
特异性
DLRB1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013],
组织表达
High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.
细胞定位
Cytoplasm, cytoskeleton.
功能
alternative products:Additional isoforms seem to exist,function:May be involved in assembly and motor function of dynein, which plays a central role in cell division and intracellular transport.,miscellaneous:Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.,similarity:Belongs to the GAMAD family.,subunit:Homodimer.,tissue specificity:High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
