BD-PT7967

OLIG2 Rabbit Polyclonal Antibody

Oligodendrocyte transcription factor 2 (Oligo2;Class B basic helix-loop-helix protein 1;bHLHb1;Class E basic helix-loop-helix protein 19;bHLHe19;Protein kinase C-binding protein 2;Protein kinase C-binding protein RACK17)

常规抗体

OLIG2 BHLHB1 BHLHE19 PRKCBP2 RACK17

OLIG2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10215

https://www.uniprot.org/uniprot/10215

Q13516

https://www.uniprot.org/uniprotkb/Q13516/entry

50913

https://www.uniprot.org/uniprot/50913

Q9EQW6

https://www.uniprot.org/uniprotkb/Q9EQW6

https://www.uniprot.org/uniprotkb/

Synthesized peptide derived from human OLIG2

This antibody detects endogenous levels of Human,Mouse,Rat OLIG2

WB 1:1000-2000 ELISA 1:5000-20000

36kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008],

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

Nucleus . Cytoplasm . The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. .

disease:A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.,domain:The bHLH is essential for interaction with NKX2-2.,function:Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.,induction:By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subcellular location:The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.,subunit:Interacts with NKX2-2.,tissue specificity:Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.