产品名称
EAA2 Rabbit Polyclonal Antibody
别名
Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II;Sodium-dependent glutamate/aspartate transporter 2;Solute carrier family 1 member 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6506
Human Swissprot No.
P43004
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P43004/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20511
Mouse Swissprot No.
P43006
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P43006
Rat Gene Link
https://www.uniprot.org/uniprot/29482
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P31596
免疫原
Synthesized peptide derived from human EAA2
特异性
This antibody detects endogenous levels of Human,Rat,Mouse EAA2
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.,PTM:Glycosylated.,similarity:Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family.,subunit:Homotrimer. Interacts with JUB.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
