BD-PT7937

syntenin Rabbit Polyclonal Antibody

Syntenin-1 (Melanoma differentiation-associated protein 9;MDA-9;Pro-TGF-alpha cytoplasmic domain-interacting protein 18;TACIP18;Scaffold protein Pbp1;Syndecan-binding protein 1)

常规抗体

SDCBP MDA9 SYCL

syntenin

WB

Human,Rat,Dog,Pig

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

6386

https://www.uniprot.org/uniprot/6386

O00560

https://www.uniprot.org/uniprotkb/O00560/entry

53378

https://www.uniprot.org/uniprot/53378

O08992

https://www.uniprot.org/uniprotkb/O08992

83841

https://www.uniprot.org/uniprot/83841

Q9JI92

https://www.uniprot.org/uniprotkb/Q9JI92

Synthesized peptide derived from human syntenin

This antibody detects endogenous levels of Human,Rat,Dog,Pig syntenin

WB 1:1000-2000 ELISA 1:5000-20000

33kD

-20°C/1 year

Polyclonal, Rabbit,IgG

syndecan binding protein(SDCBP) Homo sapiens The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.

Cell junction, focal adhesion . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus . Melanosome . Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Secreted, extracellular exosome . Membrane raft . Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966). .

function:Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.,induction:By gamma interferon in melanoma cells.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 2 PDZ (DHR) domains.,subcellular location:Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA. Interacts with neurofascin, SDCBP2 and PTPRJ.,tissue specificity:Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.