产品名称
U-PAR Rabbit Polyclonal Antibody
别名
Urokinase plasminogen activator surface receptor (U-PAR;uPAR;Monocyte activation antigen Mo3;CD antigen CD87)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5329
Human Swissprot No.
Q03405
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q03405/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18793
Mouse Swissprot No.
P35456
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P35456
Rat Gene Link
https://www.uniprot.org/uniprot/50692
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P49616
免疫原
Synthesized peptide derived from human U-PAR
特异性
This antibody detects endogenous levels of Human U-PAR
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.,similarity:Contains 3 UPAR/Ly6 domains.,subunit:Monomer (Probable). Interacts with MRC2.,
组织表达
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
细胞定位
Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. .; [Isoform 1]: Cell membrane ; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted .
功能
protein amino acid lipidation,?GPI anchor metabolic process,?GPI anchor biosynthetic process,?phospholipid metabolic process,?glycerophospholipid metabolic process,?cell motion,?chemotaxis,?blood coagulation,?hemostasis,?behavior,locomotory behavior,?lipid biosynthetic process,?phospholipid biosynthetic process,?response to wounding,?attachment of GPI anchor to protein,?organophosphate metabolic process,?regulation of proteolysis,?phosphoinositide metabolic process,?regeneration,?growth,?wound healing,?lipoprotein metabolic process,?lipoprotein biosynthetic process,?tissue regeneration,?taxis,?skeletal muscle regeneration,?glycerolipid biosynthetic process,?glycerophospholipid biosynthetic process,?glycerolipid metabolic process,?phosphoinositide biosynthetic process,?developmental growth,?coagulation,regulation of body fluid levels,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
