背景介绍
function:Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.,polymorphism:There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256.,similarity:Belongs to the fetuin family.,similarity:Contains 2 cystatin domains.,subunit:Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond.,tissue specificity:Synthesized in liver and selectively concentrated in bone matrix. Secrete din plasma. It is also found in dentin in much higher quantities than other plasma proteins.,
功能
skeletal system development,?ossification,?acute inflammatory response,?reproductive developmental process,endocytosis,?pinocytosis,?defense response,?acute-phase response,?inflammatory response,?sex differentiation,?gonad development,?male gonad development,?response to wounding,?response to endogenous stimulus,?response to hormone stimulus,?negative regulation of signal transduction,?response to organic substance,?membrane invagination,negative regulation of cell communication,?membrane organization,?vesicle-mediated transport,?telencephalon development,?pallium development,?cerebral cortex development,?regulation of endocytosis,?regulation of ossification,negative regulation of ossification,?regulation of bone mineralization,?negative regulation of bone mineralization,forebrain development,?regulation of response to external stimulus,?regulation of homeostatic process,?positive regulation of homeostatic process,?response to insulin stimulus,?cellular response to insulin stimulus,?cellular response to hormone stimulus,?regulation of tissue remodeling,?positive regulation of tissue remodeling,?response to peptide hormone stimulus,?regulation of bone resorption,?development of primary sexual characteristics,?positive regulation of bone resorption,?positive regulation of endocytosis,?development of primary male sexual characteristics,?regulation of insulin receptor signaling pathway,?negative regulation of insulin receptor signaling pathway,?male sex differentiation,regulation of bone remodeling,?positive regulation of bone remodeling,?negative regulation of response to stimulus,reproductive structure development,?regulation of inflammatory response,?regulation of phagocytosis,?positive regulation of phagocytosis,?positive regulation of transport,?positive regulation of cellular component organization,positive regulation of multicellular organismal process,?negative regulation of multicellular organismal process,?bone development,?regulation of vesicle-mediated transport,?regulation of biomineral formation,?negative regulation of biomineral formation,
