产品名称
RPAC2 Rabbit Polyclonal Antibody
蛋白名称
DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y2S0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y2S0/entry
Mouse Swissprot No.
P97304
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97304
免疫原
Synthesized peptide derived from part region of human protein
特异性
RPAC2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011],
组织表达
Cerebellum,Cervix,Colon,Eye,Kidney,Ovarian carcinoma,
细胞定位
nucleoplasm,DNA-directed RNA polymerase III complex,DNA-directed RNA polymerase I complex,cytosol,
信号通路
Purine metabolism;Pyrimidine metabolism;RNA polymerase;Cytosolic DNA-sensing pathway;
功能
function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.,similarity:Belongs to the archaeal rpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.,subunit:Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
