产品名称
MSLN Rabbit Polyclonal Antibody
别名
Mesothelin (CAK1 antigen;Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10232
Human Swissprot No.
Q13421
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13421/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56047
Mouse Swissprot No.
Q61468
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61468
Rat Gene Link
https://www.uniprot.org/uniprot/60333
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ERA7
免疫原
Synthesized peptide derived from human MSLN
特异性
This antibody detects endogenous levels of Human MSLN
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],
组织表达
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
细胞定位
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; [Megakaryocyte-potentiating factor]: Secreted.; [Isoform 3]: Secreted.
功能
disease:Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.,function:Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.,function:Membrane-anchored forms may play a role in cellular adhesion.,PTM:Both MPF and the cleaved form of mesothelin are N-glycosylated.,PTM:Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.,similarity:Belongs to the mesothelin family.,subunit:Interacts with MUC16.,tissue specificity:Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
