产品名称
PROZ Rabbit Polyclonal Antibody
别名
Vitamin K-dependent protein Z
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8858
Human Swissprot No.
P22891
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P22891/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66901
Mouse Swissprot No.
Q9CQW3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQW3
免疫原
Synthesized peptide derived from human PROZ AA range: 141-190
特异性
This antibody detects endogenous levels of Human PROZ
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],
功能
caution:Although homologous with the vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues and has no enzymatic activity.,function:Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,tissue specificity:Plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
