产品名称
Adipsin Rabbit Polyclonal Antibody
别名
Complement factor D (EC 3.4.21.46;Adipsin;C3 convertase activator;Properdin factor D)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1675
Human Swissprot No.
P00746
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P00746/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11537
Mouse Swissprot No.
P03953
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P03953
Rat Gene Link
https://www.uniprot.org/uniprot/54249
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P32038
免疫原
Synthesized peptide derived from human Adipsin AA range: 101-150
特异性
This antibody detects endogenous levels of Human Adipsin
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.,disease:Defects in CFD are the cause of complement factor D deficiency [MIM:134350]. This deficiency predisposes to invasive meningococcal disease.,function:Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.,online information:CFD mutation db,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,
功能
immune effector process,?activation of immune response,?acute inflammatory response,?activation of plasma proteins involved in acute inflammatory response,?positive regulation of immune system process,?proteolysis,?defense response,?inflammatory response,?immune response,?complement activation,?complement activation, alternative pathway,?humoral immune response,?cell surface receptor linked signal transduction,?Notch signaling pathway,response to wounding,?protein processing,?innate immune response,?positive regulation of response to stimulus,positive regulation of immune response,?protein maturation,?protein maturation by peptide bond cleavage,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
