产品名称
RBP Rabbit Polyclonal Antibody
别名
Retinol-binding protein 4 (Plasma retinol-binding protein;PRBP;RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5950
Human Swissprot No.
P02753
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P02753/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19662
Mouse Swissprot No.
Q00724
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q00724
Rat Gene Link
https://www.uniprot.org/uniprot/25703
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P04916
免疫原
Synthesized peptide derived from human RBP AA range: 11-60
特异性
This antibody detects endogenous levels of Human RBP
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
retinol binding protein 4(RBP4) Homo sapiens This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008],
组织表达
Detected in blood plasma and in urine (at protein level).
功能
disease:A deficiency of vitamin A blocks secretion of the binding protein post-translationally and results in defective delivery and supply of vitamin to the epidermal cells (a condition associated with a dermatosis).,disease:Defects in RBP4 are a cause of retinol-binding protein deficiency [MIM:180250]. This condition causes night vision problems. It produces a typical "fundus xerophthalmicus," featuring a progressed atrophy of the retinal pigment epithelium.,function:Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.,mass spectrometry: PubMed:12237133,mass spectrometry: PubMed:7666002,online information:Retina International's Scientific Newsletter,online information:Retinol-binding protein 4 entry,similarity:Belongs to the calycin superfamily. Lipocalin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
