产品名称
AGRP Rabbit Polyclonal Antibody
别名
Agouti-related protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/181
Human Swissprot No.
O00253
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00253/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11604
Mouse Swissprot No.
P56473
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P56473
免疫原
Synthesized peptide derived from human AGRP AA range: 21-70
特异性
This antibody detects endogenous levels of Human AGRP
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665].,domain:The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.,function:Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.,similarity:Contains 1 agouti domain.,tissue specificity:Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.,
组织表达
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
细胞定位
Secreted . Golgi apparatus lumen .
功能
cell surface receptor linked signal transduction,?G-protein coupled receptor protein signaling pathway,?neuropeptide signaling pathway,?intracellular signaling cascade,?behavior,?feeding behavior,?adult feeding behavior,?response to endogenous stimulus,?response to hormone stimulus,?hormone-mediated signaling,?response to organic substance,adult behavior,?cellular response to hormone stimulus,?eating behavior,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
