产品名称
IL-31RB Rabbit Polyclonal Antibody
别名
Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta;IL-31 receptor subunit beta;IL-31R subunit beta;IL-31R-beta;IL-31RB)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9180
Human Swissprot No.
Q99650
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99650/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18414
Mouse Swissprot No.
O70458
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70458
Rat Gene Link
https://www.uniprot.org/uniprot/310132
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q65Z14
免疫原
Synthesized peptide derived from human IL-31RB AA range: 501-550
特异性
This antibody detects endogenous levels of Human IL-31RB
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:Defects in OSMR are the cause of amyloidosis type 9 (AMYL9) [MIM:105250]; also known as primary cutaneous amyloidosis (PCA), primary localized cutaneous amyloidosis (PLCA), familial lichen amyloidosis or familial cutaneous lichen amyloidosis. AMYL9 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.,induction:Activated by oncostatin-M. Up-regulated by IFNG and lipopolysaccharide.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 4 fibronectin type-III domains.,subunit:Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.,tissue specificity:Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.,
组织表达
Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038).
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
regulation of acute inflammatory response,?positive regulation of acute inflammatory response,?cell surface receptor linked signal transduction,?cell proliferation,?positive regulation of cell proliferation,?response to organic substance,positive regulation of defense response,?regulation of response to external stimulus,?positive regulation of response to external stimulus,?response to cytokine stimulus,?regulation of cell proliferation,?positive regulation of response to stimulus,?regulation of inflammatory response,?positive regulation of inflammatory response,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
