产品名称
RPB9 Rabbit Polyclonal Antibody
蛋白名称
DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P36954
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P36954/entry
Mouse Swissprot No.
P60898
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P60898
免疫原
Synthesized peptide derived from part region of human protein
特异性
RPB9 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus, nucleolus .
信号通路
Purine metabolism;Pyrimidine metabolism;RNA polymerase;Huntington's disease;
功能
function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.,similarity:Contains 1 TFIIS-type zinc finger.,subunit:Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
