产品名称
RBP Rabbit Polyclonal Antibody
别名
Retinol-binding protein 4 (Plasma retinol-binding protein;PRBP;RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5950
Human Swissprot No.
P02753
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P02753/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19662
Mouse Swissprot No.
Q00724
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q00724
Rat Gene Link
https://www.uniprot.org/uniprot/25703
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P04916
免疫原
Synthesized peptide derived from human RBP AA range: 11-60
特异性
This antibody detects endogenous levels of Human RBP
宿主
Polyclonal, Rabbit,IgG
背景介绍
retinol binding protein 4(RBP4) Homo sapiens This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008],
组织表达
Detected in blood plasma and in urine (at protein level).
功能
disease:A deficiency of vitamin A blocks secretion of the binding protein post-translationally and results in defective delivery and supply of vitamin to the epidermal cells (a condition associated with a dermatosis).,disease:Defects in RBP4 are a cause of retinol-binding protein deficiency [MIM:180250]. This condition causes night vision problems. It produces a typical "fundus xerophthalmicus," featuring a progressed atrophy of the retinal pigment epithelium.,function:Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.,mass spectrometry: PubMed:12237133,mass spectrometry: PubMed:7666002,online information:Retina International's Scientific Newsletter,online information:Retinol-binding protein 4 entry,similarity:Belongs to the calycin superfamily. Lipocalin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
