产品名称
IL-34 Rabbit Polyclonal Antibody
别名
Interleukin-34 (IL-34)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/146433
Human Swissprot No.
Q6ZMJ4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZMJ4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/76527
Mouse Swissprot No.
Q8R1R4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R1R4
Rat Gene Link
https://www.uniprot.org/uniprot/498951
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4KM46
免疫原
Synthesized peptide derived from human IL-34 AA range: 51-100
特异性
This antibody detects endogenous levels of Human IL-34
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008],
组织表达
Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
功能
function:Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.,similarity:Belongs to the IL-34 family.,subunit:Homodimer.,tissue specificity:Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
