产品名称
I-TAC Rabbit Polyclonal Antibody
别名
C-X-C motif chemokine 11 (Beta-R1;H174;Interferon gamma-inducible protein 9;IP-9;Interferon-inducible T-cell alpha chemoattractant;I-TAC;Small-inducible cytokine B11)
基因名称
CXCL11 ITAC SCYB11 SCYB9B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6373
Human Swissprot No.
O14625
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14625/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56066
Mouse Swissprot No.
Q9JHH5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JHH5
免疫原
Synthesized peptide derived from human I-TAC AA range: 45-94
特异性
This antibody detects endogenous levels of Human I-TAC
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:Expressed in a variety of skin disorders, including allergic contact dermatitis, lichen planus and mycosis fungoides.,function:Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.,induction:By interferon gamma and interferon beta. Induction by IFN-gamma is enhanced by TNF-alpha in monocytes, dermal fibroblasts and endothelial cells, and by IL-1 in astrocytes.,mass spectrometry: PubMed:10233762,online information:CXCL11 entry,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,tissue specificity:High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.,
组织表达
High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
功能
chemotaxis,?defense response,?inflammatory response,?immune response,?cell surface receptor linked signal transduction,?G-protein coupled receptor protein signaling pathway,?cell-cell signaling,?behavior,?locomotory behavior,response to wounding,?taxis,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
