产品名称
Acrogranin Rabbit Polyclonal Antibody
别名
Granulins (Proepithelin;PEPI) [Cleaved into: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2896
Human Swissprot No.
P28799
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P28799/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/0
Mouse Swissprot No.
P28798
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P28798
Rat Gene Link
https://www.uniprot.org/uniprot/29143
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P23785
免疫原
Synthesized peptide derived from human Acrogranin AA range: 541-590
特异性
This antibody detects endogenous levels of Human Acrogranin
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.,function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.,function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.,PTM:Granulins are disulfide bridged.,similarity:Belongs to the granulin family.,tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.,
组织表达
In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
细胞定位
Secreted . Lysosome . Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity). .
功能
in utero embryonic development,?blastocyst development,?blastocyst hatching,?female pregnancy,?embryo implantation,?positive regulation of cell proliferation,?embryonic development ending in birth or egg hatching,?hatching,regulation of cell proliferation,?chordate embryonic development,?regulation of epithelial cell proliferation,?positive regulation of epithelial cell proliferation,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
