产品名称
CD94 Rabbit Polyclonal Antibody
别名
Natural killer cells antigen CD94 (KP43;Killer cell lectin-like receptor subfamily D member 1;NK cell receptor;CD antigen CD94)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3824
Human Swissprot No.
Q13241
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13241/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16643
Mouse Swissprot No.
O54707
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O54707
Rat Gene Link
https://www.uniprot.org/uniprot/25110
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O35778
免疫原
Synthesized peptide derived from human CD94 AA range: 124-173
特异性
This antibody detects endogenous levels of Human CD94
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed in NK cell subsets (at protein level) (PubMed:21825173, PubMed:9430220, PubMed:9485206). Expressed in memory/effector CD8-positive alpha-beta T cell subsets (at protein level) (PubMed:12387742, PubMed:20952657). Expressed in melanoma-specific cytotoxic T cell clones (at protein level) (PubMed:9485206). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level) (PubMed:20952657). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20952657).
细胞定位
Cell membrane ; Single-pass type II membrane protein .
功能
function:Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.,online information:CD94,similarity:Contains 1 C-type lectin domain.,subunit:Can form disulfide-bonded heterodimer with NKG2 family members.,tissue specificity:Natural killer cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
