产品名称
CD43 Rabbit Polyclonal Antibody
别名
Leukosialin (Galactoglycoprotein;GALGP;Leukocyte sialoglycoprotein;Sialophorin;CD antigen CD43)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6693
Human Swissprot No.
P16150
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P16150/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20737
Mouse Swissprot No.
P15702
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P15702
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P13838
免疫原
Synthesized peptide derived from human CD43 AA range: 1-80
特异性
This antibody detects endogenous levels of Human CD43
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011],
组织表达
Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
细胞定位
Membrane ; Single-pass type I membrane protein . Cell projection, microvillus . Cell projection, uropodium . Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). .; [CD43 cytoplasmic tail]: Nucleus . Nucleus, PML body . The sumoylated form localizes to the PML body. .
功能
disease:CD43 expression is defective on the T-cells of males with the immunodeficiency Wiskott-Aldrich syndrome. Affected males are susceptible to opportunistic infections and do not respond to polysaccharide antigens, reflecting defects in cytotoxic and helper T-cell functions.,function:One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.,PTM:Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.,subunit:Interacts with HIPK2 via the cytoplasmic domain.,tissue specificity:Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
