产品名称
Pdcd-1 Rabbit Polyclonal Antibody
别名
Programmed cell death protein 1 (Protein PD-1;hPD-1;CD antigen CD279)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5133
Human Swissprot No.
Q15116
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15116/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18566
Mouse Swissprot No.
Q02242
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q02242
免疫原
Synthesized peptide derived from human Pdcd-1 AA range: 80-130
特异性
This antibody detects endogenous levels of Human Pdcd-1
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Single-pass type I membrane protein.
功能
developmental stage:Induced at programmed cell death.,disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
