产品名称
Actin-pan Rabbit Polyclonal Antibody
别名
Actin, aortic smooth muscle (Alpha-actin-2;Cell growth-inhibiting gene 46 protein)
基因名称
ACTA2 ACTSA ACTVS GIG46
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/59
Human Swissprot No.
P62736/P60709/P68032/P63261/P63267/P68133
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P62736/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11475
Mouse Swissprot No.
P62737
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P62737
Rat Gene Link
https://www.uniprot.org/uniprot/81633
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P62738
免疫原
Synthesized peptide derived from human Actin-pan
特异性
This antibody detects endogenous levels of Human,Mouse,Rat Actin-pan
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008],
细胞定位
Cytoplasm, cytoskeleton.
功能
disease:Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the actin family.,subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
