产品名称
14-3-3-pan Rabbit Polyclonal Antibody
别名
14-3-3 protein beta/alpha (Protein 1054;Protein kinase C inhibitor protein 1;KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7529
Human Swissprot No.
P31946/P61981/P27348/P63104/P31947
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P31946/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/54401
Mouse Swissprot No.
Q9CQV8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQV8
Rat Gene Link
https://www.uniprot.org/uniprot/56011
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P35213
免疫原
Synthesized peptide derived from human 14-3-3-pan
特异性
This antibody detects endogenous levels of Human,Mouse,Rat 14-3-3-pan
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Vacuole membrane . (Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG. .
功能
function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.,PTM:Isoform Short contains a N-acetylmethionine at position 1.,PTM:The alpha, brain-specific form differs from the beta form in being phosphorylated.,similarity:Belongs to the 14-3-3 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
