产品名称
IL1RA Rabbit Polyclonal Antibody
别名
Interleukin-1 receptor antagonist protein (IL-1RN;IL-1ra;IRAP;ICIL-1RA;IL1 inhibitor;Anakinra)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3557
Human Swissprot No.
P18510
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P18510/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16181
Mouse Swissprot No.
P25085
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P25085
Rat Gene Link
https://www.uniprot.org/uniprot/60582
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P25086
免疫原
Synthesized peptide derived from human IL1RA
特异性
This antibody detects endogenous levels of Human IL1RA
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:Genetic variation in IL1RN is associated with susceptibility to diabetic nephropathy [MIM:612628]; also called susceptibility to microvascular complications of diabetes type 4 (MVCD4). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,function:Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis.,similarity:Belongs to the IL-1 family.,tissue specificity:The intracellular form of IL1RN is predominantly expressed in epithelial cells.,
组织表达
The intracellular form of IL1RN is predominantly expressed in epithelial cells.
细胞定位
[Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm.
功能
defense response,?inflammatory response,?immune response,?response to wounding,?response to endogenous stimulus,?response to hormone stimulus,?response to organic substance,?response to corticosteroid stimulus,response to steroid hormone stimulus,?response to glucocorticoid stimulus,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
