产品名称
RAB25 Rabbit Polyclonal Antibody
别名
Ras-related protein Rab-25 (CATX-8)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57111
Human Swissprot No.
P57735
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P57735/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/53868
Mouse Swissprot No.
Q9WTL2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTL2
免疫原
Synthesized peptide derived from human RAB25 AA range: 80-160
特异性
This antibody detects endogenous levels of Human RAB25
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015],
组织表达
Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue.
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell projection, pseudopodium membrane . Cytoplasmic vesicle . Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. .
功能
function:May selectively regulate the apical recycling and/or transcytotic pathways.,similarity:Belongs to the small GTPase superfamily. Rab family.,subunit:Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
