产品名称
RPA12 Rabbit Polyclonal Antibody
蛋白名称
DNA-directed RNA polymerase I subunit RPA12 (Zinc ribbon domain-containing protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9P1U0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P1U0/entry
Mouse Swissprot No.
Q791N7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q791N7
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6MFY5
免疫原
Synthesized peptide derived from part region of human protein
特异性
RPA12 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Peripheral blood leukocyte,Skeletal muscle,Skin,
细胞定位
Nucleus, nucleolus .
信号通路
Purine metabolism;Pyrimidine metabolism;RNA polymerase;
功能
function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.,similarity:Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.,similarity:Contains 1 TFIIS-type zinc finger.,subunit:Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
