产品名称
RPAC2 Rabbit Polyclonal Antibody
蛋白名称
DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y2S0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y2S0/entry
Mouse Swissprot No.
P97304
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97304
免疫原
Synthesized peptide derived from part region of human protein
特异性
RPAC2 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011],
组织表达
Cerebellum,Cervix,Colon,Eye,Kidney,Ovarian carcinoma,
细胞定位
nucleoplasm,DNA-directed RNA polymerase III complex,DNA-directed RNA polymerase I complex,cytosol,
信号通路
Purine metabolism;Pyrimidine metabolism;RNA polymerase;Cytosolic DNA-sensing pathway;
功能
function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.,similarity:Belongs to the archaeal rpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.,subunit:Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
