产品名称
RSK3 (Phospho Thr353) Rabbit Polyclonal Antibody
别名
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2;EC 2.7.11.1;90 kDa ribosomal protein S6 kinase 2;p90-RSK 2;p90RSK2;MAP kinase-activated protein kinase 1c;MAPK-activated protein kinase 1c;MAPKAP kinase 1c;MAPKAPK-1c;Ribosomal S6 kinase 3;RSK-3;pp90RSK3)
基因名称
RPS6KA2 MAPKAPK1C RSK3
蛋白名称
RSK3 (Phospho Thr353)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6196
Human Swissprot No.
Q15349
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15349/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20112
Mouse Swissprot No.
Q9WUT3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WUT3
免疫原
Synthesized peptide derived from human RSK3 (Phospho Thr353)
特异性
This antibody detects endogenous levels of Human,Mouse RSK3 (Phospho Thr353)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-377, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.,
组织表达
Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
细胞定位
Nucleus . Cytoplasm .
功能
protein amino acid phosphorylation,?phosphorus metabolic process,?phosphate metabolic process,?intracellular signaling cascade,?protein kinase cascade,?phosphorylation,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
