产品名称
eIF2B (Phospho Ser67) Rabbit Polyclonal Antibody
别名
Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta;eIF-2-beta)
蛋白名称
eIF2B (Phospho Ser67)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8894
Human Swissprot No.
P20042
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P20042/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67204
Mouse Swissprot No.
Q99L45
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99L45
免疫原
Synthesized peptide derived from human eIF2B (Phospho Ser67)
特异性
This antibody detects endogenous levels of Human eIF2B (Phospho Ser67)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
eukaryotic translation initiation factor 2 subunit beta(EIF2S2) Homo sapiens Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
功能
function:eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.,similarity:Belongs to the eIF-2-beta/eIF-5 family.,subunit:Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
