产品名称
14-3-3σ (Phospho Ser186) Rabbit Polyclonal Antibody
别名
14-3-3 protein sigma (Epithelial cell marker protein 1;Stratifin)
蛋白名称
14-3-3σ (Phospho Ser186)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2810
Human Swissprot No.
P31947
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P31947/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/55948
Mouse Swissprot No.
O70456
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70456
免疫原
Synthesized peptide derived from human 14-3-3σ (Phospho Ser186)
特异性
This antibody detects endogenous levels of Human,Mouse 14-3-3σ (Phospho Ser186)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,
组织表达
Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
细胞定位
Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.
功能
function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
