产品名称
ROS (Phospho Tyr2114) Rabbit Polyclonal Antibody
别名
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1;Proto-oncogene c-Ros;Proto-oncogene c-Ros-1;Receptor tyrosine kinase c-ros oncogene 1;c-Ros receptor tyrosine kinase)
蛋白名称
ROS (Phospho Tyr2114)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6098
Human Swissprot No.
P08922
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P08922/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19886
Mouse Swissprot No.
Q78DX7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q78DX7
Rat Gene Link
https://www.uniprot.org/uniprot/25346
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63132
免疫原
Synthesized peptide derived from human ROS (Phospho Tyr2114)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat ROS (Phospho Tyr2114)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008],
组织表达
Expressed in brain. Expression is increased in primary gliomas.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.,function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 fibronectin type-III domains.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
