产品名称
DNA2 Rabbit Polyclonal Antibody
蛋白名称
DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P51530
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P51530/entry
Mouse Swissprot No.
Q6ZQJ5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6ZQJ5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941D3ZG52
免疫原
Synthesized peptide derived from part region of human protein
特异性
DNA2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014],
组织表达
Bone marrow,Colon,Duodenum,Lymph,
细胞定位
Nucleus. Mitochondrion. Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). .
功能
function:May function in chromosomal DNA replication.,similarity:Belongs to the DNA2/NAM7 helicase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
