背景介绍
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions.,domain:The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL.,function:Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.,PTM:Phosphorylated on 6 tyrosine residues upon activation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Constituent of focal adhesions.,subunit:Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with RGNEF and SHB (By similarity). Interacts with TGFB1I1.,tissue specificity:Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.,
功能
microtubule cytoskeleton organization,?cell morphogenesis,?cell morphogenesis involved in differentiation,angiogenesis,?blood vessel development,?vasculogenesis,?neuron migration,?vasculature development,?protein complex assembly,?protein amino acid phosphorylation,?phosphorus metabolic process,?phosphate metabolic process,cell motion,?cytoskeleton organization,?microtubule-based process,?cell surface receptor linked signal transduction,enzyme linked receptor protein signaling pathway,?transmembrane receptor protein tyrosine kinase signaling pathway,?signal complex assembly,?integrin-mediated signaling pathway,?cell-cell signaling,?synaptic transmission,axonogenesis,?negative regulation of cell development,?regulation of cell morphogenesis involved in differentiation,regulation of neuron projection development,?phosphorylation,?cell migration,?transmission of nerve impulse,?central nervous system neuron differentiation,?central nervous system neuron development,?central nervous system neuron axonogenesis,?regulation of cell morphogenesis,?cell projection organization,?neuron differentiation,?extracellular matrix organization,?neuron projection development,?regulation of cell projection organization,?negative regulation of cell projection organization,?cellular component morphogenesis,?cell part morphogenesis,?cellular macromolecular complex subunit organization,?cellular macromolecular complex assembly,?regulation of growth,?establishment of nucleus localization,?extracellular structure organization,?endothelial cell migration,?cellular protein complex assembly,macromolecular complex subunit organization,?regulation of cellular component biogenesis,?negative regulation of cell differentiation,?regulation of neuron differentiation,?negative regulation of growth,?regulation of organ growth,negative regulation of organ growth,?protein amino acid autophosphorylation,?blood vessel morphogenesis,?neuron development,?cell morphogenesis involved in neuron differentiation,?neuron projection morphogenesis,?cell projection morphogenesis,?cell motility,?regulation of neurogenesis,?negative regulation of neurogenesis,?regulation of axonogenesis,?negative regulation of axonogenesis,?regulation of synapse structure and activity,?regulation of synapse organization,?neurological system process,?negative regulation of cellular component organization,?organelle localization,?nucleus localization,?establishment of organelle localization,?localization of cell,?regulation of nervous system development,?negative regulation of nervous system development,?regulation of synaptogenesis,?negative regulation of synaptogenesis,?regulation of cell development,?macromolecular complex assembly,?protein complex biogenesis,
