BD-PP1599

LRP6 (Phospho Thr1479) Rabbit Polyclonal Antibody

Low-density lipoprotein receptor-related protein 6 (LRP-6)

常规抗体

LRP6

LRP6 (Phospho Thr1479)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

4040

https://www.uniprot.org/uniprot/4040

O75581

https://www.uniprot.org/uniprotkb/O75581/entry

16974

https://www.uniprot.org/uniprot/16974

O88572

https://www.uniprot.org/uniprotkb/O88572

Synthesized peptide derived from human LRP6 (Phospho Thr1479)

This antibody detects endogenous levels of Human,Mouse LRP6 (Phospho Thr1479)

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

177kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009],

Widely coexpressed with LRP5 during embryogenesis and in adult tissues.

Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum . Membrane raft . On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). .

disease:Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2) [MIM:610947].,domain:The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1.,function:Essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.,similarity:Belongs to the LDLR family.,similarity:Contains 20 LDL-receptor class B repeats.,similarity:Contains 3 LDL-receptor class A domains.,similarity:Contains 4 EGF-like domains.,subunit:Interacts with RSPO1 and RSPO3 (By similarity). Interacts with FZD5. Essential component of the Wnt7 receptor complex. Wnt7A interacts with the LRP6/FZD5 complex. This interaction is antagonized by DKK1 and DKK3.,tissue specificity:Widely co-expressed with LRP5 during embryogenesis and in adult tissues.,

现货

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.