产品名称
EPHA3 (Phospho Tyr602) Rabbit Polyclonal Antibody
别名
Ephrin type-A receptor 3 (EC 2.7.10.1;EPH-like kinase 4;EK4;hEK4;HEK;Human embryo kinase;Tyrosine-protein kinase TYRO4;Tyrosine-protein kinase receptor ETK1;Eph-like tyrosine kinase 1)
基因名称
EPHA3 ETK ETK1 HEK TYRO4
蛋白名称
EPHA3 (Phospho Tyr602)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2042
Human Swissprot No.
P29320
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P29320/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/0
Mouse Swissprot No.
P29319
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P29319
Rat Gene Link
https://www.uniprot.org/uniprot/29210
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O08680
免疫原
Synthesized peptide derived from human EPHA3 (Phospho Tyr602)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat EPHA3 (Phospho Tyr602)
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. Highest level in placenta.
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Widely expressed. Highest level in placenta.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
