背景介绍
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.,enzyme regulation:Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation.,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.,function:This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.,PTM:Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts with TXNL2/PICOT.,tissue specificity:Skeletal muscle, megakaryoblastic cells and platelets.,
功能
regulation of cell growth,?response to hypoxia,?regulation of cytokine production,?positive regulation of immune system process,?regulation of leukocyte activation,?positive regulation of leukocyte activation,?protein amino acid phosphorylation,?proteolysis,?membrane protein ectodomain proteolysis,?phosphorus metabolic process,?phosphate metabolic process,?intracellular signaling cascade,?regulation of mitotic cell cycle,?aging,?positive regulation of cell proliferation,?macromolecule catabolic process,?response to temperature stimulus,?response to heat,?response to wounding,?response to abiotic stimulus,?response to endogenous stimulus,?response to hormone stimulus,?response to carbohydrate stimulus,?response to hexose stimulus,?response to glucose stimulus,?positive regulation of biosynthetic process,?response to organic substance,?regulation of G2/M transition of mitotic cell cycle,?positive regulation of macromolecule biosynthetic process,?regulation of cell cycle process,?positive regulation of macromolecule metabolic process,?positive regulation of organelle organization,?response to organic cyclic substance,phosphorylation,?regulation of vasoconstriction,?protein catabolic process,?neuron differentiation,?regeneration,positive regulation of cellular biosynthetic process,?regulation of cell projection organization,?positive regulation of cell projection organization,?regulation of actin filament bundle formation,?positive regulation of actin filament bundle formation,?regulation of intracellular transport,?positive regulation of intracellular transport,?regulation of interleukin-2 production,?response to insulin stimulus,?regulation of protein localization,?regulation of mononuclear cell proliferation,positive regulation of mononuclear cell proliferation,?regulation of actin cytoskeleton organization,?regulation of actin filament-based process,?regulation of organelle organization,?regulation of intracellular protein transport,?membrane protein proteolysis,?response to monosaccharide stimulus,?growth,?regulation of growth,?regulation of cytokine biosynthetic process,?wound healing,?positive regulation of T cell proliferation,?positive regulation of cytokine biosynthetic process,?regulation of cell proliferation,?regulation of T cell proliferation,?tissue regeneration,?regulation of protein import into nucleus,?positive regulation of protein import into nucleus,?regulation of NF-kappaB import into nucleus,?positive regulation of NF-kappaB import into nucleus,?regulation of transcription factor import into nucleus,positive regulation of transcription factor import into nucleus,?positive regulation of DNA binding,?response to peptide hormone stimulus,?regulation of system process,?regulation of cellular component biogenesis,?positive regulation of molecular function,?cellular protein catabolic process,?cellular macromolecule catabolic process,?regulation of interleukin-2 biosynthetic process,?positive regulation of interleukin-2 biosynthetic process,?regulation of transcription,respiratory burst,?regulation of nucleocytoplasmic transport,?positive regulation of nucleocytoplasmic transport,developmental growth,?regulation of lymphocyte proliferation,?positive regulation of lymphocyte proliferation,regulation of protein secretion,?positive regulation of protein secretion,?regulation of T cell activation,?regulation of cell activation,?positive regulation of cell activation,?positive regulation of T cell activation,?regulation of secretion,?positive regulation of secretion,?positive regulation of transport,?regulation of transcription factor activity,?positive regulation of transcription factor activity,?positive regulation of NF-kappaB transcription factor activity,?regulation of binding,?positive regulation of binding,?regulation of DNA binding,?positive regulation of cellular component organization,?positive regulation of protein transport,?regulation of protein transport,?regulation of lymphocyte activation,?positive regulation of lymphocyte activation,?regulation of filopodium assembly,?positive regulation of filopodium assembly,?regulation of stress fiber formation,?regulation of cytoskeleton organization,?positive regulation of cytoskeleton organization,positive regulation of stress fiber formation,?proteolysis involved in cellular protein catabolic process,?regulation of cell cycle,?regulation of cellular localization,?regulation of cell projection assembly,?regulation of establishment of protein localization,?response to oxygen levels,?regulation of leukocyte proliferation,?positive regulation of leukocyte proliferation,
