产品名称
AXL (Phospho Tyr697) Rabbit Polyclonal Antibody
别名
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1;AXL oncogene)
蛋白名称
AXL (Phospho Tyr697)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/558
Human Swissprot No.
P30530
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P30530/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/26362
Mouse Swissprot No.
Q00993
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q00993
免疫原
Synthesized peptide derived from human AXL (Phospho Tyr697)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat AXL (Phospho Tyr697)
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
组织表达
Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia.,function:May function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Heterodimer and heterotetramer with GAS6.,tissue specificity:Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
